Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Effect of Acidic Polysaccharide of Red Ginseng on Lipolytic action of Toxohormone-L from Cancerous Ascites Fluid

홍삼의 산성다당체 성분이 암독소 호르몬-L의 지방분해에 미치는 영향

  • Lee, Sunh-Dong (2nd Department of Medical Biochemistry, School of Medicine, Ehime University) ;
  • Kameda, Kenji (Central Research Laboratory, School of Medicine, Ehime University) ;
  • Takaku, Takeshi (Central Research Laboratory, School of Medicine, Ehime University) ;
  • Sekiya, Keizo (2nd Department of Medical Biochemistry, School of Medicine, Ehime University) ;
  • Hirose, Kumi (Institute of pharmaceutical Sciences, School of Medicine, Hiroshima University) ;
  • Ohtani, Kazuhiro (Institute of pharmaceutical Sciences, School of Medicine, Hiroshima University) ;
  • Tanaka, Osamu (Institute of pharmaceutical Sciences, School of Medicine, Hiroshima University) ;
  • Okuda, Hiromichi (Central Research Laboratory, School of Medicine, Ehime University)
  • Published : 1990.04.01
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Abstract

Toxohorome-L is a lipolytic factor found in ascites fluid of sarcoma 180-bearing mice and of patients with hepatoma. A substance that inhibited the lipolytic action of Toxohormone-L was isoialed from red ginseng powder. This substance had a pectin-like o 1, 4-pollrgalacturonan backbone with some acetoxyl groups, and so was an acidic polysaccharide. It inhibited Toxohormone-L-induced lipolysis in a dose dependent manner at concentrations higher than 10 $\mu\textrm{g}$/ml.

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