대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

가감삼기탕(加減三寄湯) 전탕액(煎湯液)이 가토(家兎) 혈장(血漿) COrtisol 농도(濃度) 및 혈장(血漿) $PCO_2,\;PO_2$에 미치는 영향(影響)

Effects of Ga Gam Sam Kee Tang Water Extract on the Plasma Cortisol Concentration and Arterial Blood $PCO_2,\;PO_2$ in the Rabbit

  • Lee, Seung-Woo (Dept. of Oriental Medicine Graduate School Wonkwang University) ;
  • Han, Sang-Whan (Dept. of Oriental Medicine Graduate School Wonkwang University)
  • 발행 : 1990.12.31
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초록

To evaluate effects of Ga Gam Sam Kee Tang(GGSKT) water extract on the plasma cortisol concentration and arterial blood $PCO_2,\;PO_2$ in the rabbit. The results obtained were as follows : 1. Intravenous administration of GGSKT water at the dose of $0.2m{\ell}/kg$ remarkably increased plasma cortisol concentration from 1 to 2 hours. 2. Oral administration of GGSKT water extract at the dose of $10m{\ell}/kg$ significantly decreased plasma cortisol concentration on 3 hours. 3. Intravenous administration of GGSKT water extract at the dose of $0.4m{\ell}/kg$ remarkably decreased arterial blood $PO_2$ on 2 hours. 4. Oral administration of GGSKT water extract at the dose of $1.0m{\ell}/kg$ significantly decreased arterial blood $PO_ 2$ on 2 hours and remarkably increased on 4 hours. 5. Intravenous administration of GGSKT water extract at the dose of $0.2m{\ell}/kg$ remarkably increased arterial blood $PCO_2$ on 4 hours. 6. Oral administration of GGSKT water extract at the dose of $2.0m{\ell}/kg$ significantly decreased arterial blood $PCO_2$ from 1 to 2 hours. These results suggest that therapeutic action of GGSKT water extract for athma may be related with the increment of plasma cortisol concentration and the decrease of arterial blood $PCO_2$.

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