아세트아미노펜의 결정다형에 관한 연구

Study on the Polymorphism of Acetaminophen

The metastable modification of acetaminophen was prepared in industry scale. It was found that the dissolution rate of the metastable modification was greater than that of the original powder. The metastable modification was transformed to the stable modification by grinding, but it was not transformed by compression. Starch and lactose inhibited this transformation of the metastable modification to the stable modification by grinding.