생약학회지 (Korean Journal of Pharmacognosy)
- 제21권2호
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- Pages.179-185
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- 1990
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- 0253-3073(pISSN)
- /
- 2288-9299(eISSN)
가미쌍화탕류(加味雙和湯類)의 독성(毒性) 및 약효연구(藥效硏究)
The Acute and Subacute Toxicities and Pharmacological Actions of Gami Ssanghwa Tang Preparations
-
Shin, Kuk-Hyun
(Natural Products Research institute, Seoul National University)
;
-
Lee, Eun-Bang
(Natural Products Research institute, Seoul National University)
;
- Jung, Myung-Sook (Natural Products Research institute, Seoul National University) ;
- Kim, Oon-Ja (Natural Products Research institute, Seoul National University) ;
- Yoon, Ki-Young (Natural Products Research institute, Seoul National University)
- 발행 : 1990.06.30
초록
The acute and subacute toxicities and pharmacological actions of two preparations of Ssanghwa Tang prescriptions have been evaluated in mice, rats and rabbits. The two prescriptions were found to be safe drugs because those preparations exhibited almost no acute and subacute toxicities even at a high dosage level. The two prescriptions elicited CNS depressant activities characterized by potentiation of hexobarbital-induced narcosis, antipyretic activity in typhoid-vaccinated rabbits and a significant antifatigue effect against cold immobilized stress, the activities of prescription B being more potent.
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