약학회지 (YAKHAK HOEJI)
- 제34권6호
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- Pages.375-383
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- 1990
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Haloperidol의 약물속도론적 연구 (III) -정신분열증 환자에 있어서 Haloperidol의 일회 주사 및 경구투여시의 Pharmacokinetics-
Pharmacokinetics of Haloperidol (III) -The Pharmacokinetics of Haloperidol after single oral and intravenous doses in schizophrenic patients-
- 박경호 (서울대학교병원 약제부) ;
- 이민화 (서울대학교병원 약제부,서울대학교 약학대학) ;
- 이명걸 (서울대학교병원 약제부,서울대학교 약학대학) ;
- 권준수 (국군수도병원 정신과) ;
- 박원명 (국군수도병원 정신과) ;
- 박진생 (국군수도병원 정신과)
- Park, Kyoung-Ho (Dept. of Pharmacy, Seoul National University Hospital) ;
- Lee, Min-Hwa (Dept. of Pharmacy, Seoul National University Hospital,College of Pharmacy, Seoul National University) ;
- Lee, Myung-Gull (Dept. of Pharmacy, Seoul National University Hospital,College of Pharmacy, Seoul National University) ;
- Kwon, Jun-Soo (Dept. of Psychiatry, Capital Armed Forces Genernal Hospital) ;
- Park, Won-Myung (Dept. of Psychiatry, Capital Armed Forces Genernal Hospital) ;
- Park, Jin-Seng (Dept. of Psychiatry, Capital Armed Forces Genernal Hospital)
- 발행 : 1990.12.28
초록
The pharmacokinetics of haloperidol were determined after single oral and intravenous doses in 13 male schizophrenic patients. Plasma concentrations of haloperidol(HP) and reduced haloperidol(RH) were measured by high performance liquid chromatography. Plasma concentration data obtained were analyzed by obth model dependent (one-or two exponential decay models using nonlinear regression) and model independent (AUC and first moment curve) approaches. The two methods were found to be in close results. After intravenous injections of HP in 8 patients (10 mg/man), the mean central and peripheral volume of distributions were
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