YAKHAK HOEJI (약학회지)
- Volume 34 Issue 5
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- Pages.341-347
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- 1990
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Effects of Panax ginseng on Galactosamine-induced Cytotoxicity in Primary Cultured Rat Hepatocytes
인삼 분획물이 Galactosamine에 의하여 손상된 일차배양한 흰쥐의 간세포에 미치는 영향
- Song, Jin-Ho (College of Pharmacy, Seoul National University) ;
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Park, Mi-Jung
(College of Pharmacy, Seoul National University) ;
- Kim, Eun (Korea Ginseng and Tobacco Research Institute) ;
- Kim, Young-Choong (College of Pharmacy, Seoul National University)
- Published : 1990.10.28
Abstract
The anti-hepatotoxic activity of Panax ginseng was studied using galactosamine (GalN)-induced cytotoxicity in primary cultured rat hepatocytes. Panax ginseng was fractionated into dammarane glycosides and protein fractions. The dammarane glycosides was further fractionated into panaxadiol and panaxatriol glycosides fractions. The protein fraction was further fractionated into four groups according to the molecular weight; larger than 10,000 dalton, between 5,000 and 10,000 dalton, between 1,000 and 5,000 dalton and between 500 and 1,000 dalton. A significant lowering action on the elevated glutamicpyruvic transaminase (GPT) activity in the culture medium of hepatocytes treated with 1.5 mM GalN was noticed with all four protein fractions studied at the concentration of both
Keywords
- Panax ginseng;
- Dammarane glycosides fraction;
- Protein fraction;
- Primary cultured rat hepatocytes;
- Galactosamine-induced cytotoxicity