약학회지 (YAKHAK HOEJI)
- 제34권4호
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- Pages.244-251
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- 1990
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Ditertiary Diamine의 Regiospecific N-, N'-Monoalkyl화 반응
Rigiospecific N-, N'-Monoalkylation of Ditertiary Diamines
- Jang, Ji-Hyang (College of Pharmacy, Chonnam National University) ;
- Choi, Bo-Gil (College of Pharmacy, Chonnam National University) ;
- Chung, Byung-Ho (College of Pharmacy, Chonnam National University)
- 발행 : 1990.08.28
초록
N-Monoalkylations of ditertiary diamines succeed best in nitromethane or ethanol at low temperature. Unsymmetrical 1,2-diaminoethane, 1,3-diaminopropane and piperazine compounds react selectively under these conditions at the sterically less hindered nitrogen atom.
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