YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Effect of Phenazine Dioxide Derivatives on the Hepatic Xanthine Oxidase Activity

Phenazine dioxide 유도체가 간 Xanthine Oxidase 활성에 미치는 영향

  • Kang, Il-Young (Department of Organic Chemistry, College of Pharmacy, Hyosung Women's University) ;
  • Kim, Sang-Yul (Department of Organic Chemistry, College of Pharmacy, Hyosung Women's University) ;
  • Kim, Ho-Shik (Department of Chemistry, Teachers College, Hyosung Women's University) ;
  • Huh, Keun (Department of Pharmacology, College of Pharmacy, Yeungnam University)
  • 강일영 (효성여자대학교 약학대학) ;
  • 김상렬 (효성여자대학교 약학대학) ;
  • 김호식 (효성여자대학교 사범대학 화학과) ;
  • 허근 (영남대학교 약학대학)
  • Published : 1990.04.30
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Abstract

8-Acyl-2-hydroxyphenzaine -5, 10-dioxides and 8-acyl-2-aminophenazine-5, 10-dioxides bearing n-butanoyl, n-hexanoyl and n-octanoyl groups were synthesized. It was attempted to observe the effect of phenazine dioxide derivatives on the hepatic xanthine oxidase activity in this study. As the activity of xanthine oxidase, the key enzyme in the generation of superoxide anion radical ($O_2$), was measured in the presence of phenazine dioxide derivatives, the action of 8-acyl-2-hydroxyphenazine-5,10-dioxide derivatives inhibited with increase of numbers of carbon atom bearing 8-acyl group. Moreover, when plotted on double reciprocal form, the Vmax value decrease as increase of numbers of carbon atom bearing acyl groups without affecting the Km value. However, the hepatic xanthine oxidase activity was not changed by 8-acyl-2-aminophenazine-5,10-dioxide derivatives.

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