The Korean Journal of Physiology
- 제24권1호
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- Pages.131-144
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- 1990
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- 0300-4015(pISSN)
가토 신장기능에 미치는 Pro-Atrial Natriuretic Peptide의 영향
Effects of Intrarenal Arterial Infusion of Pro-Atrial Natriuretic Peptides on Renal Function in Unanesthetized Rabbits
- Lee, Jeong-Eun (Department of Anesthesiology, Chungnam National University Medical School) ;
- Cho, Kyung-Woo (Department of Physiology, Jeonbug National University Medical School) ;
- Kim, Suhn-Hee (Department of Physiology, Jeonbug National University Medical School)
- 발행 : 1990.06.30
초록
It is well known that the atrial natriuretic peptide (ANP) has a prepro-hormone of 151 amino-acids which loses their hydrophobic signal peptide to form 126 amino acid prohormone. The whole prohormone is released and then cleaved by proteases into more than one circulating forms. Recently, Winters et al. (1988a, b) reported that high concentrations of N-terminal fragments of prepro-ANP