Journal of Yeungnam Medical Science

영남대 의대 학술지 편집위원회 (Yeungnam University College of Medicine, Yeungnam University Institute Medical Science)
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소세포폐암에 동반된 Eaton-Lambert Syndrome 1례

Eaton-Lambert Syndrome with Small Cell Lung Cancer -A case report-

  • 이경희 (영남대학교 의과대학 내과학교실) ;
  • 정문관 (영남대학교 의과대학 내과학교실) ;
  • 현명수 (영남대학교 의과대학 내과학교실) ;
  • 정재천 (영남대학교 의과대학 내과학교실) ;
  • 이현우 (영남대학교 의과대학 내과학교실) ;
  • 하정상 (영남대학교 의과대학 신경과학교실) ;
  • 변영주 (영남대학교 의과대학 신경과학교실)
  • Lee, Kyeong-Hee (Department of internal medicine, College of Medicine, Yeungnam University) ;
  • Chung, Moon-Kwan (Department of internal medicine, College of Medicine, Yeungnam University) ;
  • Hyun, Myung-Soo (Department of internal medicine, College of Medicine, Yeungnam University) ;
  • Chung, Jae-Chun (Department of internal medicine, College of Medicine, Yeungnam University) ;
  • Lee, Hyun-Woo (Department of internal medicine, College of Medicine, Yeungnam University) ;
  • Hah, Jung-Sang (Department of Neurology, College of Medicine, Yeungnam University) ;
  • Byun, Yeung-Ju (Department of Neurology, College of Medicine, Yeungnam University)
  • 발행 : 1989.06.30
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초록

저자들은 영남대학병원에 입원한 52세 남자환자로서 임상소견, 조직소견, 근전도 소견상으로 소세포폐암과 동반된 Eaton-Lambert 증후군으로 진단된 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Eaton Lambert Syndrome(ELS)is a disorder of neuromuscular transmission. The defect of neuromuscular transmission is due to decrease in the release of acetylcholine guanta from nerve terminal. This syndrome is frequently associated with bronchogenic carcinoma. The diagnosis is established by electromyography, which characteristically shows 1) low amplitude of evoked compound muscle potential to a single supramaximal stimulus on nerve, 2) significant decremental response at low rates of stimulation 3) marked incremental response at high rates of stimulation. Our patient is 52year old man with dyspnea, coughing and muscle weakness of proximal lower limbs. He has small cell lung cancer and associated with ELS, Superior venacava syndrome and has metastatic lesion on right supraclavicular lymphnode confirmed by pathology. Metastatic mass and SVC syndrome are marked improved following chemotherapy and radiotherapy, however follow up EMG finding does not improved. We are here reporting one case which considered compatible for ELS, with a few elementary reviewed literatures.

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