Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Liquid Chromatographic Resolution of 2-Hydroxy Acids on Chiral Stationary Phases : A Mechanistic Consideration

  • Myung Ho Hyun (Department of Chemistry, Pusan National University) ;
  • Chung-Sik Min (Department of Chemistry, Pusan National University)
  • Published : 1989.12.20
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Abstract

Two enantiomers of various 2-hydroxy acid esters have been resolved as the 3,5-dinitrophenyl carbamates on chiral stationary phases (CSPs) derived from ${\alpha}-arylalkylamines.$ Two CSPs, each of which contains the same type of chiral moiety, but shows different mode of connection to a silica support, have been found to show the contrasting resolution behaviors. From the contrasting resolution behaviours of two CSPs used in this study, two competing chiral recognition mechanisms are proposed.

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  1. Optical Resolution of Racemic α-Hydroxycarboxylic Acids on a Dynamic Chiral Stationary Phase Derived from (S)-Leucinol by Ligand Exchange Chromatography vol.25, pp.11, 1989, https://doi.org/10.5012/bkcs.2004.25.11.1707