Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Estimation of Activtiy Against Adenocarcinoma CA755 and Toxicity of Purines in Mice Using Physicochemical Parameter and Connectivity Index

  • Park Byung-Kak (Department of Chemistry, Yeungnam University) ;
  • Kim Ho-Soon (Department of Chemistry, Yeungnam University) ;
  • Suh Man-Chul (Department of Material Treatment ITTI, Korea Institue of Machinery and Metals) ;
  • Lee Gab-Yong (Department of Chemical Education, Hyosung Women's University) ;
  • Paek U-Hyon (Department of Chemistry, Gyeongsang University)
  • Published : 19890200
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Abstract

The nonempirical molecular connectivity indexes of a number of mono- and disubstituted purines were calculated. Very good correlations were obtained between anticancer activity (log 1/c) and toxic activity (log 1/) of tIhese compounds and their molecular connectivity indexes and physicochemical constants. Our structure-activity relationship is discussed briefly in relation to theories of general QSAR.

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