Toxicological Research
- 제5권2호
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- Pages.135-149
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- 1989
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
EFFECTS OF GANODERMA LUCIDUM EXTRACT ON THE DEVELOPMENT OF RAT LIVER PRENEOPLASTIC LESIONS
- Kim, Jong-Soo (College of Veterinary Medicine Seoul National University) ;
- Lee, Yong-Soon (College of Veterinary Medicine Seoul National University)
- 발행 : 1989.12.01
초록
The effect of Ganoderma lucidum (Polyporaceae) extract on initiation and promotion of liver preneoplastic lesions in chemical carcinogenesis were examined in male rats. Male Fisher 344 rats, 8 weeks old, were injected i.p. with diethylnitro-samine(DENA` 200 mg/kg) as an initiator and were fed on diet containing 0.02%-acetaminofluorene (2-AAF) as a promoter for 2 weeks (group 1, 2` 2-4 week) and were fed on basal diet (group 3 and 4). The rats in test groups(group 1 and 3) were fed on diet containing 0.1% of Ganoderma lucidum extract for 6 weeks (2-8 week).
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