Toxicological Research
- Volume 5 Issue 2
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- Pages.105-109
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- 1989
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
ACUTE TOXICITY OF HANTABAX (HFRS-VACCINE) IN RATS AND MICE
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Moon, Chang-Kiu
(College of Phamacy Seoul National University)
;
- Park, Kwang-Sik (College of Phamacy Seoul National University) ;
- Mock, Myung-Soo (College of Phamacy Seoul National University) ;
- Jung, Myung-Kiu (College of Phamacy Seoul National University) ;
- Kim, Ji-Young (College of Phamacy Seoul National University)
- Published : 1989.12.01
Abstract
Single dose of Hantabax, HFRS-vaccine, was given to both sexes of Sprague-Dawley rats and ICR mice, subcutaneously and intraperitoneally. Any toxic symptom was not noted in the treated animals. Macroscopic examination on the organs of tested animals showed no abnormal findings. In general toxicological aspects Hantabax was practically nontoxic in rats and mice upto a single dose of 1000 times of human clinical dose equivalent via subcutaneous and intraperitoneal administration.