Toxicological Research
- Volume 5 Issue 2
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- Pages.97-104
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- 1989
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
GENERATION OF p-DINITROBENZENE ATMOSPHERE AND METHEMOGLOBIN FORMATION IN RATS
Abstract
A new exposure system was developed to generate p-dinitrobenzene (p-DNB) containing atmosphere. A glass column was filled with small glass beads coated with the chemical. The p-DNB containing medium was heated to a temperature beyond the boiling point of p-DNB. A stream of air flow was forced to pass through the column and let it mixed with fresh air before introducing into an inhalation chamber. The concentration of p-DNB in the chamber air was measured by direct assaying the air directly and by sampling the chemical using a microfilter installed in the chamber.