한국대기환경학회지 (Journal of Korean Society for Atmospheric Environment)
- 제5권1호
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- Pages.62-67
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- 1989
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- 1598-7132(pISSN)
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- 2383-5346(eISSN)
마우스 골수 소핵 시험에 의한 디젤분진, $HgCl_2$ 및 $Pb(Ac)_2$ 의 유전독성효과
Genotoxic Effects of Diesel Emission Particle Extract, $HgCl_2$ and $Pb(Ac)_2$ by the Mouse Bone Marrow Micronucleus Test
초록
The clastogenic effects of the diesel emission particle extract (DEPE), mercuric chloride and lead acetate were examined by the mouse bone marrow micronucleus test. DEPE had a potent clastogenic effect by intraperitoneal injection with dose-response between 100 and 300mg/kg b.w.. Mercuric chloride and lead acetate also gave a clastogenic effects but mercuric chloride only had a dose-response between 1 and 3mg/kg b.w.. When DEPE was administrated with mercuric chloride or lead acetate, the frequency of micronucleated cells was slight but not significant increase in comparision to a single treatment with DEPE alone.
키워드