Archives of Pharmacal Research
- Volume 12 Issue 4
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- Pages.259-262
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- 1989
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Synthesis and antimickrobial activity of benzofuran-carboxamide derivatives
- Hishmat, O.H. (Chemistry of Natural Products Department, N.R.C.) ;
- Nasef, A.M. (Chemistry of Natural Products Department, N.R.C.) ;
- El-Naem, Sh.I.A. (Chemistry of Natural Products Department, N.R.C.) ;
- Shalaby, A.M. (Botany Department, Faculty of Science, Cairo University)
- Published : 1989.12.01
Abstract
The reaction of the sodium salts of 4-methoxy and 4, 7-dimethoxy 6-hydroxy benzofuran-5-carboxylic acid with ethyl chloroformate yields the corresponding dicarbethoxy derivatives. The N-substituted amides were obtained by treating the latter compounds with amines. The corresponding hydrazides were synthesized by the reaction of hydrazine hydrate on the dicarbethoxy derivatives which spontaneously cyclized to 5-substituted-2, 3- dihydro-1, 3, 4, -oxadiazol-2-one. Also the reaction with phenyl hydrazine has been studied. The dicarbethoxy derivatives and N-substituted amides were tested against Gram positive and Gram negative bacteria in vitro. Most of the compounds posses moderate or slight activity against Gram positive bacteria.