Journal of Pharmaceutical Investigation
- Volume 19 Issue 3
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- Pages.117-121
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- 1989
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Development of Optically Active Chelate Resin for Direct Resolution of Enantiomers(III)-Synthesis of Copper(II) L-Proline Chelate Resin and Resolution of Enantiomers-
Enantiomer의 분리에 이용될 수 있는 Chelate Resin의 개발(제 3보)-Copper(II) L-Proline Chelate Resin의 제조 및 Enantiomer 분리-
- Kim, Kil-Soo (College of Pharmacy, Ewha Womans University) ;
- Jeon, Dong-Won (College of Home Economics, Ewha Womans University)
- Published : 1989.09.20
Abstract
A metal complex, copper (II) L-proline was chemically bound to ethylene glycol dimethacrylate and divinylbenzene crosslinked chloromethylated polystyrene and they were used as chiral chelate resin matrix for column chromatography to resolve enantiomers of DL-amino acids. The L-enantiomers eluted first and the degree of resolution on the polymer crosslinked with ethylene glycol dimethacrylate was superior to the polymer crosslinked with divinylbenzene.