Archives of Pharmacal Research
- 제12권2호
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- Pages.88-93
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- 1989
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Effects of Molecular Weights on the Physico-pharmaceutical Properties of Poly-L-glutamic acid-cytarabine Conjugates
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Kim, Chong-Kook
(College of Pharmacy, Seoul National University) ;
- Kwon, Kyoung-Ae (College of Pharmacy, Seoul National University) ;
- Jeong, Eun-Ju (College of Pharmacy, Seoul National University) ;
- Lee, Myung-Gull (College of Pharmacy, Seoul National University)
- 발행 : 1989.06.01
초록
In order to obtain some informations about the effect of molecular weight on the release rate of drug from drug carrier, two types of poly-L-glutamic acid (PLGA)-cytarabine (ara-C) conjugates, PLGA-ara-C:I and PLGA-ara-C:II, were synthesized using two types of PLGA having different average molecular weight, 43,000 and 77,800, respectively. The PLGA-ara-C conjugates were synthesized by mixed anhydride method and found to be covalently linked. Both types of conjugates charged negatively at biological pH. The pH-dependent release rate of ara-C was observed in both cases, and the release rate was accelerated in basic, acidic conditions (the k values were 0.015
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