Bromolactonization of 2-Substituted-1-Cyclohexenyl-1-acetic acid

2-치환-1-Cyclohexenyl-1-acetic acid의 브롬락톤화 반응

Bromolactonization of 2-Substituted-1-cyclohexenyl-1-acetic acid (1) with 1,3-dibromo-5,5-dimethylhydantoin (dibromantin) in N,N-dimethylformamide gave the corresponding ${\gamma}-bromo-{\beta}-lactone$ (2) and ${\beta}-bromo-{\gamma}-lactone$ (3). The effect of the substituents, the reaction temperature, and the solvent on the regioselectivity was discussed.