YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
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Effects of Earthworm (Lamnodrilus gotai Hatai) Extract on the Hepatotoxicity of Carbon Tetrachloride in Rats

사염화(四鹽化) 탄소(炭素)에 의한 흰쥐의 간장기능(肝臟機能) 장애(障碍)와 토룡(土龍)엑기스의 투여효과(投與效果)

  • Chung, Yong (The Institute for Environmental Research, Yonsei University) ;
  • Lee, Hyo-Min (The Institute for Environmental Research, Yonsei University)
  • 정용 (연세대학교 환경공해연구소) ;
  • 이효민 (연세대학교 환경공해연구소)
  • Published : 1989.04.28
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Abstract

These studies were attempted to investigate the therapeutic effect earthworm (Lamnodrilus gotai Hatai) extract (LS) on the liver damage induced by carbon tetrachloride ($CCl_4$) in rats. Male rats (Sprague-Dawley) were treated with sub-chronic concentration of $CCl_4$, which was 0.2 ml/kg of $CCl_4$ via peroral administration twice a week. LS administration to rats (6 ml/kg,po) prevented the development of fatty liver, necrosis and fibrosis induced by $CCl_4$. Furthermore, as compared with rats suspended after treated with $CCl_4$ only, LS treatment significantly decreased the increment in serum enzyme activities, liver enlargement and improved growth rate. This protective effect was observed when LS was given monthly for 4 months after $CCl_4$ treated for 2 months. These results suggest that earthworm extract has appreciable therapeutic effect on $CCl_4$-induced hepatotoxicity.

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