Abstract
To obtain the basic data for protective roles and first-aid of radiation hazard, the present studies were carried out to evaluate the decontamination of radiostrontium by the First-Aid drugs. Each mouse was administered intraperitoneally dose of sodium alginate 5mg, $CaNa_3DTPA$ 8.4mg and saline 5ml following the internal contamination with 1 $\mu$Ci of strontium as $^{85}SrCl_2$. $^{85}Sr$ was determined by the radioactivity of body burden, urinary excretion, fecal excretion and organ distribution by Ge-detector and MCA. The results are summarized as follows. 1. Effective half life on whole body retention $^{85}Sr$ was determined at 33 hours. 2. The decontamination effect of First-Aid durgs on the body $^{85}Sr$ burden were increased $CaNa_3DTPA$ (4.7 times), sodium alginate (1.7 times) and saline (2.4 times) respectively. 3. Strontium were excreted through urine (35.4%), feces (64.4%) and other (0.2%). But on the $^{85}Sr$ excretion routes following First-Aid drugs treatment, strontium-85 mainly were excreted through urine after $CaNa_3DTPA$ and saline treatment, and was excreted through feces after sodium alginate treatment. 4. The organ distribution of strontium-85 is vertebra, femur, sternum and liver in order Finally, the extrapolations from these data to victims were suggested that the rapid administration of $CaNa_3DTPA$, sodium alginate and saline simultaneously were markedly increased the decontamination effects on the internal contamination of radiostrontium.
방사성 물질 체내 오염에 대한 진단에 필요한 기초 자료를 얻기 위하여 $^{85}SrCl_2\;1{\mu}Ci$를 NIH(GP) 마우스의 복강내 투여로 체내 오염시키고, $CaNa_3DTPA$ 8.4 mg, sodium alginate 5 mg 및 saline 5 ml등을 병행 투여로 응급 처치한 후 경과 시간에 따라 도살 부검하여 중요 장기 및 배설물의 방사능을 측정하였다. 그 결과 방사성 스트론튬에 대한 단기간의 유효 반감기는 33 시간으로 나타났으며 각 처치제의 배설효과는 $CaNa_3DTPA$가 4.7배, sodium alginate가 1.7배, 그리고 saline이 2.4배 이었다. 스트론튬 단독 투여군의 체내 축적은 척추(脊椎), 대퇴골(大腿骨), 흉골(胸骨), 간장(肝臟)의 순이었으며, 배설 경로는 요(尿) 35.4%, 변(便) 64.4% 및 기타 0.2%이었고, $CaNa_3DTPA$ 및 saline 투여군은 주로 뇨, 그리고 sodium alginate 투여군은 변(便)을 통하여 배설하였다. 이로부터 방사성 스트론튬 체내 오염에 대한 응급 처치는 $CaNa_3DTPA$, sodium alginate 및 saline등을 병행 투여함으로써 방사선 피폭을 경감시킬 것으로 사료 되었다.