The Korean Journal of Pain
- Volume 1 Issue 1
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- Pages.64-73
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- 1988
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- 2005-9159(pISSN)
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- 2093-0569(eISSN)
Effect of Epidural Morphine and Bupivacaine with Hypertonic Solution or the Duration of Analgesia
경막외 Morphine, Bupivacaine 및 고장성용액 혼주시 진통지속효과에 미치는 영향
- Park, Wook (Department of Anesthesiology, School of Medicine, Soon Chun Hyang College) ;
- Park, Kwang-Won (Department of Anesthesiology, Yonsei University, College of Medicine)
- Published : 1988.06.30
Abstract
Recent studios have shown that narcotic drags produce an unusually intense, prolonged and segmental analgesic action in man whoa injected into the spinal subarachnoid or epidural space (Wang et al, 1979; Behar et al, 1979; Cousins et al, 1979; Magora et a., 1980, Johnston and McCaughey, 1980). Since 1960, many investigators claimed that low molecular weight(LMW) dextran increased the clinical duration of lidocaine(Loder, 1960; Loder, 1962), tetracaine (Chinn and Wirjoatmadja, 1967) and bupivacaine(Kaplan et al, 1975) in man but the mechanism of the action of dextran was unclear. But Curtiss and Scurlock(1979), and Buckled and Fink(1979) claimed that LMW dextran has no effect on the duration of action of bupivacaine in animal studies. The present study was performed to evaluate the clinical efficacy of analgesia by the thoracic epidural injection of morphine and bupivacaine mixture for the relief of pain due to fractured or contused ribs, to evaluate the duration of analgesic effect by the use of the above mixture in a hypertonic solution(dextran 70 or 50% dextrose in water) and to observe the possibility of improvement in the lung function after the pain block. The complications following the pain block were also observed. The 50 single thoracic epidural injections of the mixture were divided into three groups : Group 1(n=15) served as a control group and drags used for the relief of pain were as follows(Mean
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