Journal of Preventive Medicine and Public Health
- Volume 21 Issue 1 Serial No. 23
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- Pages.152-162
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- 1988
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- 1975-8375(pISSN)
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- 2233-4521(eISSN)
Effect of STEL-toluene on Metabolism of Benzene in Rats
단시간 허용농도의 toluene이 benzene대사에 미치는 영향
- Roh, Jae-Hoon (Department of Preventive Medicine and Public Health College of Medicine Yonsei University) ;
-
Shin, Dong-Chun
(Department of Preventive Medicine and Public Health College of Medicine Yonsei University) ;
- Park, Jung-Gyun (Department of Preventive Medicine and Public Health College of Medicine Yonsei University) ;
- Moon, Young-Hahn (Department of Preventive Medicine and Public Health College of Medicine Yonsei University) ;
- Chung, Ho-Keun (The Institute for Pneumoconiosis, Korea Welfare Corporation)
- 노재훈 (연세대학교 의과대학 예방의학교실) ;
-
신동천
(연세대학교 의과대학 예방의학교실) ;
- 박정균 (연세대학교 의과대학 예방의학교실) ;
- 문영한 (연세대학교 의과대학 예방의학교실) ;
- 정호근 (근로복지공사 진폐연구소)
- Published : 1988.05.01
Abstract
Benzene and toluene, which are widely used aromatic hydrocarbons in workplace, are recently proved to cause health hazards due to their toxic effects. This study investigated the influence of toluene on the urinary excretion of benzene metabolite by administering short term exposure limit(STEL) of these compounds(i.e., 13.8mg/kg of benzene and 108.8 mg/kg of toluene) intraperitoneally into Sprague-Dawley rats. After administration, urinary phenol concentration of rat was measured by gas chromatography for every three hours. Data were analyzed by non-parametric statistical methods using Kruskal-Wallis multi-sample test and Mann-Whitney U test. The following results were obtained : 1. Administration of STEL-benzene increased urinary phenol concentration in lats. 2. Urinary phenol concentration was increased logarithmically according to the dosage of benzene. 3. Excretion of phenol in urine was decreased when benzene and toluene were administered simultaneously compared with administering benzene alone. In summary, these results reveal that administration of STEL of toluene has antagonistic effect of urinary excretion of benzene metabolite in rats.
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