대한수의학회지 (Korean Journal of Veterinary Research)
- 제28권1호
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- Pages.37-47
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- 1988
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- 2466-1384(pISSN)
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- 2466-1392(eISSN)
닭의 근위운동에 미치는 Xylazine hydrochloride, Yohimbine hydrochloride 및 4-Aminopyridine의 영향
Effect of Xylazine hydrochloride, Yohimbine hydrochloride, and 4-Aminopyridine on Gizzard Motility in Chicken
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Kim, Kil-su
(College of Veterinary Medicine, Kyungpook National University) ;
- Park, Joon-hyoung (College of Veterinary Medicine, Kyungpook National University)
- 투고 : 1988.02.01
- 발행 : 1988.04.30
초록
Xylazine hydrochloride is a widely used analgesic, sedative and muscle relaxant agent in veterinary clinic. Yohimbine hydrochloride and 4-aminopyridine are known as antagonists of xylazine hydrochloride. This paper was investigated to know that the effect of xylazine hydrochloride, yohimbine hydrochloride and 4-aminopyridine, and that whether or not antagonism of yohimbine hydrochloride and 4-aminopyridine to xylazine hydrochloride-induced effect on gizzard motility in chicken. The results were as follows. 1. After xylazine hydrochloride administration, the gizzard motility in chicken was instantly inhibited in relaxation state, and this state was prolonged in proportion to increase of dose. 2. After yohimbine hydrochloride administration, the gizzard motility in chicken showed increase of contractile frequency. 3. After 4-aminopyridine administration, the gizzard motility in chicken was gradually recovered next to decrease of contractile amplitude and frequency. 4. After the combination of yohimbine hydrochloride and 4-aminopyridine administration, the gizzard motility in chicken showed increase of amplitude and radical increase of frequency. 5. After xylazine hydrochloride administration, the relaxation time was shortened by yohimbine hydrochloride, 4-aminopyridine and the combination of yohimbine hydrochloride and 4-aminopyridine. In conclusion, the gizzard motility in chicken was inhibited by xylazine hydrochloride, and this effect was antagonized by the combination of yohimbine hydrochloride and 4-aminopyridine.
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