Asian-Australasian Journal of Animal Sciences
- Volume 1 Issue 3
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- Pages.139-142
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- 1988
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- 1011-2367(pISSN)
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- 1976-5517(eISSN)
DOI QR Code
EFFECTS OF CHRONIC INGESTION OF ANTHRANILIC ACID ON MAMMARY GLAND GROWTH IN SHN MICE
- Nagasawa, H. (Animal Breeding and Experimental Animal Research Laboratory Meiji University) ;
- Konishi, R. (Animal Breeding and Experimental Animal Research Laboratory Meiji University) ;
- Sakagami, N. (Animal Breeding and Experimental Animal Research Laboratory Meiji University) ;
- Inatomi, H. (Laboratory of Natural Product Chemistry Meiji University)
- Received : 1988.03.11
- Accepted : 1988.09.13
- Published : 1988.09.01
Abstract
Effects of anthranilic acid on normal mammary gland growth were examined in SHN/Mei female virgin mice. Anthranilic acid was given to the experimental groups as drinking water at the concentrations of 0.01, 0.02 or 0.04% for 21 days beginning 2-3 months of age. The control group received tap water only. RNA content and RNA/DNA ratio in mammary glands were significantly higher in mice given 0.04% anthranilic acid than in the control, while not mammary DNA content. The results indicate that chronic ingestion of anthranilic acid can induce an enhancement of proliferation and differentiation of mammary cells.