Bulletin of the Korean Chemical Society

  • 제9권5호
  • /
  • Pages.271-274
  • /
  • 1988
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  • 0253-2964(pISSN)
  • /
  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Mechanistic Studies on the Photochemical Degradation of Nifedipine

  • Shim, Sang-Chul (Department of Chemistry, Korea Advanced Institute of Science and Technology) ;
  • Pae, Ae-Nim (Department of Chemistry, Korea Advanced Institute of Science and Technology) ;
  • Lee, Yong-Jai (Pharmacy Research and Development, Ayerst Laboratories, Inc.)
  • 발행 : 1988.10.20
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초록

Irradiaton of nifedipine in methylene chloride at 366 nm yielded 2,6-dimethyl-3,5-dicarbomethoxy-4-(2'-nitrosophen yl)-pyridine with the quantum yield 0.37, while irradiation at 254 nm initially gave nitroso compound which in turn is photooxidized to 2,6-dimethyl-3,5-dicarbomethoxy-4-(2'-nitrophenyl) -pyridine with the quantum efficiency of 0.014 on further irradiation in the presence of oxygen. The intramolecular hydrogen abstraction of nifedipine proceeded from the triplet excited sitate.

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참고문헌

  1. J. Chromatogr. v.210 Piergiorgio Pietta;Angelo Rava;Pierantonio Biondi
  2. Drugs of the Future v.4 J. Prous;P. Blancafort;J. Castaner;M.N. Serradell;N. Mealy
  3. Arzenium-Forsch. v.22 H. Medenwald;K. Schlossmann;C. Wunsche
  4. II Farmaco, Ed. Prak. v.34 R. Testa;E. Dolfini;C. Reschiotto;C. Secchi;P.A. Biondi
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  8. The Chemistry of the Nitro and Nitroso Groups H. A. Morrison
  9. Arch. Pharm. v.314 K. Gorlitzer;D. $Bu{\beta}$
  10. Topics in Current Chemistry v.55 D. Dopp
  11. The Chemistry of Nitro and Nitroso Groups C.N.R. Rao;K. R. Bhaskar
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피인용 문헌

  1. Polarographic and Spectrophotometric Determination of Nimodipine in Tablets vol.25, pp.2, 1988, https://doi.org/10.1080/00032719208018526
  2. Voltammetric behavior of 1,4-dihydropyridine calcium antagonists vol.6, pp.3, 1988, https://doi.org/10.1002/elan.1140060313
  3. Spectrophotometric and electrochemical study of the inclusion complex between β-cyclodextrin and furnidipine vol.35, pp.1, 1988, https://doi.org/10.1016/j.jpba.2003.12.015
  4. Photochemistry of 4-(2-Nitrophenyl)-1,4-Dihydropyridines. Evidencefor Electron Transfer and Formation of an Intermediate vol.82, pp.1, 1988, https://doi.org/10.1562/2005-06-01-ra-561
  5. Factors Affecting the Release of Nifedipine from a Swellable Elementary Osmotic Pump vol.15, pp.1, 2008, https://doi.org/10.1080/10717540701829028
  6. Study on degradation kinetics of epalrestat in aqueous solutions and characterization of its major degradation products under stress degradation conditions by UHPLC-PDA-MS/MS vol.9, pp.6, 1988, https://doi.org/10.1016/j.jpha.2018.08.002