Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Mechanistic Studies on the Photochemical Degradation of Nifedipine

  • Shim, Sang-Chul (Department of Chemistry, Korea Advanced Institute of Science and Technology) ;
  • Pae, Ae-Nim (Department of Chemistry, Korea Advanced Institute of Science and Technology) ;
  • Lee, Yong-Jai (Pharmacy Research and Development, Ayerst Laboratories, Inc.)
  • Published : 1988.10.20
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Abstract

Irradiaton of nifedipine in methylene chloride at 366 nm yielded 2,6-dimethyl-3,5-dicarbomethoxy-4-(2'-nitrosophen yl)-pyridine with the quantum yield 0.37, while irradiation at 254 nm initially gave nitroso compound which in turn is photooxidized to 2,6-dimethyl-3,5-dicarbomethoxy-4-(2'-nitrophenyl) -pyridine with the quantum efficiency of 0.014 on further irradiation in the presence of oxygen. The intramolecular hydrogen abstraction of nifedipine proceeded from the triplet excited sitate.

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