Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Convenient Synthesis of Chiral trans-2-Phenylcyclopropanecarboxylic Acid

  • Cho, Nam-Sook (Department of Chemistry, College of Natural Sciences Chungnam National University) ;
  • Shin, Dae-Hyun (Department of Chemistry, College of Natural Sciences Chungnam National University) ;
  • Lee, Chong-Chul (Department of Chemistry, College of Natural Sciences Chungnam National University) ;
  • Ra, Do-Young (Department of Chemistry, College of Natural Sciences Chungnam National University)
  • Published : 1988.08.20
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Abstract

(-)-(1R, 2R) and (+)-(1S, 2S)-menthyl-trans-2-phenylcyclopropanecarboxylat e have been synthesized with the aid of chiral Cu(II) complex catalyst by the addition reaction of l-menthyldiazoacetate to styrene. The yield was 75%, with the purity of trans isomer over 95% and the optical purity of 95%.

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References

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  1. ChemInform Abstract: Convenient Synthesis of Chiral trans‐2‐Phenylcyclopropanecarboxylic Acid. vol.20, pp.8, 1989, https://doi.org/10.1002/chin.198908150
  2. NMR-based Enantiodifferentiation of Chiral trans-2-Phenylcyclopropane Derivatives Using a Chiral Lanthanide Shift Reagent vol.32, pp.6, 2011, https://doi.org/10.5012/bkcs.2011.32.6.2076