Effects of Carcinogens and Partial Hepatectomy on the Nitrogen Utilizing and the Xenobiotic Metabolizing Enzymes in the Hepatic Tissues of Rats

발암원과 부분간절제술 처리에 의한 백서 간 조직중 질소이용계 및 이물질 대사계 효소의 변화

The biochemical changes of the hepatic tissues, induced by the carcinogen treatment such as diethylnitrosamine and acetamidofluorene in combination with the partial hepatectomy after Solt and Farber, were determined for the characterization of the induction of the proliferative capacity and the environmental adaptability of the carcinogenic tissues during the malignant transformation process. For the study of the proliferative capacity of the tissues, the activities of the enzymes, related with the nitrogen trapping mechanism, such as glutamine synthetase and gamma-glutamyltranspeptidase, were monitroed, while the cintents of cytochrome P450's and their isozymic patterns as well as the activities of the glutathione S-transferase were determined in the function of time after the hepatocarcinogenic stimuli.