A Study on the Antilipidperoxidative Effects of Brazilin(II)

천연색소 Brazilin의 항지질 과산화 활성에 관한 연구(II)

A great deal of attention has been directed recently at the roles played by lipidperoxides in the mediation of pathogenesis and complications of various disease. In view of the strong inhibitory activity of Brazilin on the lipidperoxidation, we examined the effect of Brazilin on the lipidperoxidation in diabetic states. Brazilin inhibited the lipidperoxidation of liver mitochondrial and microsomal fraction in alloxan-induced diabetic ICR mice in the dose and time dependent manner. In the light of the present results, further elucidation of the inhibitory activities of Brazilin on the liver and blood plasma is warrented.

Alloxan으로 유도된 당뇨병상태에서 Brazilin 투여시 mitochondira 분획 및 microsome 분획에서 용량의존적으로 억제효과가 증가하였으며 Brazilin 100mg/kg을 투여시는 mitochondria 분획에서 56.7% 억제를 , microsome 분획에서는 68.4%의 억제효과를 보였다. 또한 Brazilin 100mg/kg을 시간별 투여시 시간의존적으로 억제효과가 증가하였으며 30일간 투여시에 mitochondria 분획에서 66.2%, microsome 분획에서 74.3%의 억제효과를 보았다.