Adaptive On-line Optimization of Cellular Productivity of Continuous Methylotroph Culture

메타놀자화균의 연속배양에 의한 균체생산의 온-라인 적응최적화

An adaptive on-line optimization method has been applied to test the ability to maximize the cellular productivity of a continuous methylotroph culture system which was simulated by a variable yield Monod-type model. Optimum dilution rate and productivity were successively obtained and maintained at all times by the algorithm that utilizes steepest descent technique as optimization method and recursive least-square method with forgetting factor as dynamic model identification.