Pubetalin, the Cytotoxic Principle of Siegesbeckia pubescenes Makino against L1210 Cell

털진득찰의 L1210 세포독성물질 Pubetalin의 분리

A cytotoxic sesquiterpene against L1210 cell, named pubetalin. was isolated from the herb of Siegesbeckia pubescens Makino. Its structure was identified as $6-formyl-2,\;3,\;3{\alpha},\;4,\;5,\;8,\;9,\;11{\alpha}-octahydro-10-hydroxymethyl-5-methoxy-3-methylene-2-oxocyclodeca[{\beta}]\;furan-4-ylester$ of 2-methyl-2-propenoic acid.