Studies on the Efficacy of Combined Preparation of Crude Drugs(XXXVI) -Effects of Sipmidojuksan on the Central Nervous and Cardiovascular Systems-

생약복합제제(生藥複合製劑)의 약효연구(藥效硏究)(제36보)(第36報) -십미도적산(十味導赤散)이 중추신경계(中樞神經系) 및 순환기계(循環器系)에 미치는 영향(影響)-

The sedative, antipyretic, analgesic and anticonvulsive action, action on the isolated ileum in mice, retricting action on edema, action on blood pressure and respiration of Sipmidojuksan were evaluated. The results were as follows; sedative effects were recognized by the unbalanced effects of spontaneous momentum by wheel cage method, muscle relaxing action by rotor rod method and prolongation of sleeping hours. In mice, a significant antipyretic effect to endotoxin was recognized. Significant anagesic effects by acetic acid and Randall-Sellito method were recognized. Significant anticonvulsive effects to strychnine and picrotoxin were recognized. Spontaneous momentum of isolated ileum in mice was restricted, and relaxing effects on smooth muscle of digestive organ were noted by anti-acetylcholine, anti-barium chloride and anti-histamine effects. Significant antiedemic effects to carrageenin and histamine were recognized. Dilatation of blood vessels and decrease of blood pressure were noted.