Studies on the Hemostatic Action and the Effects on the Isolated Uterus Muscle of Combined Preparation of Crude Drugs ( I ) -On Kwibitang-

복합생약제제(複合生藥製劑)의 지혈작용(止血作用) 및 적출자궁근(摘出子宮筋)에 미치는 영향(影響)(제1보)(第1報) -귀비탕(歸脾湯)에 대(對)하여-

Experimental studies were conducted to investigate the hemostatic effect of the water extracts of Kwibitang. For this purpose, the effects of the extracts on the bleeding time in mouse tail and prothrombin time in vitro were estimated. Furthermore, its activity on the isolated uterine muscle in rats were investigated. The results obtained were as following; The bleeding time was not shortened, but the plasma prothrombin time in vitro test was significantly shortened. The uterotonic action produced by the extract was not inhibited by pretreatment of diltiazem at the doses of $10^{-5}g/ml$.