약학회지 (YAKHAK HOEJI)
- 제32권6호
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- Pages.415-419
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- 1988
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
혈장내 Pentoxifylline과 Metabolite(I)의 HPLC에 의한 분석
Determination of Pentoxifylline and Metabolite(I) by HPLC
- Min, Byeong-Sun (College of Pharmarcy, Kyung Hee University) ;
- Choung, Se-Young (College of Pharmarcy, Kyung Hee University) ;
- Rho, Young-Soo (College of Pharmarcy, Kyung Hee University) ;
- Youn, Byoung-Ho (Han Dok Remedia) ;
- Lim, Soo-Han (Han Dok Remedia)
- 발행 : 1988.10.30
초록
A rapid and simple method for the determination of pentoxifylline and its major metabolite, metabolte(I) in plasma was examined by HPLC. For the purification and enrichment of drug from plasma, solid-phase extraction was examined using Sep-pak C18 cartridge. The effectiveness of test method was proved by monitoring of the rat after oral administration of pentoxifylline in a dose of 40mg/kg.
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