YAKHAK HOEJI (약학회지)
- Volume 32 Issue 6
- /
- Pages.415-419
- /
- 1988
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
Determination of Pentoxifylline and Metabolite(I) by HPLC
혈장내 Pentoxifylline과 Metabolite(I)의 HPLC에 의한 분석
- Min, Byeong-Sun (College of Pharmarcy, Kyung Hee University) ;
-
Choung, Se-Young
(College of Pharmarcy, Kyung Hee University)
;
-
Rho, Young-Soo
(College of Pharmarcy, Kyung Hee University)
;
- Youn, Byoung-Ho (Han Dok Remedia) ;
- Lim, Soo-Han (Han Dok Remedia)
- Published : 1988.10.30
Abstract
A rapid and simple method for the determination of pentoxifylline and its major metabolite, metabolte(I) in plasma was examined by HPLC. For the purification and enrichment of drug from plasma, solid-phase extraction was examined using Sep-pak C18 cartridge. The effectiveness of test method was proved by monitoring of the rat after oral administration of pentoxifylline in a dose of 40mg/kg.
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