YAKHAK HOEJI (약학회지)
- Volume 32 Issue 6
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- Pages.386-393
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- 1988
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Optimization of the Transformation of D-Glucose to Vitamin C
Glucose를 비타민 C로 변형시키는 과정의 최적화에 대한 연구
- Chung, Jong-Kyeong (Department of Pharmacy, Seoul National University) ;
- Goo, Yang-Mo (Department of Pharmacy, Seoul National University) ;
- Kim, Kong-Hwan (Department of Biotechnology, Ajou University)
- Published : 1988.10.30
Abstract
Chemical transformation of D-glucose to 2-keto-L-gulonic acid and L-ascorbic acid has been examined. D-Sorbitol obtained from D-glucose was microbiologically oxidized to L-sorbose by G. suboxydans in 90% yield. On treatment of L-sorbose with acetone in the presence of sulfuric acid, its diacetonide is obtained in 95% yield. This diacetonide is oxidized to the corresponding acid with nickel chloride-hypochlorite, and the acid is directly transformed to L-ascorbic acid. The over all yield of Vitamin C from D-glucose achieved is 54%.
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