Effect of Polysorbate 40 on Properties of Cytarabine Carnauba Wax Microspheres

시타라빈의 카르나우바왁스 Microsphere의 성질에 미치는 폴리소르베이트 40의 영향

The effect of polysorbate 40, used as a surfactant during the process of manufacture, on the properties of cytarabine microspheres with carnaubu wax was studied. It was revealed that the mean particle size increased in proportion to the concentration of polysorbate 40, and that the dissolution rate of the cytarabine from the microspheres decreased greatly more than the cytarabine powder only, but increased in proportion to the concentration of polysorbate 40 as surfactant.