약학회지 (YAKHAK HOEJI)

  • 제32권4호
  • /
  • Pages.230-233
  • /
  • 1988
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Doxorubicin유발 심장독성에 미치는 L-Carnitine의 효과

Effect of L-Carnitine on the Cardioxicity Induced by Doxorubicin

  • 김형춘 (중앙대학교 의과대학 병리학교실) ;
  • 송계용 (중앙대학교 의과대학 병리학교실) ;
  • 전구석 (중앙대학교 약학대학) ;
  • 허인회 (중앙대학교 약학대학)
  • Kim, Hyoung-Chun (Department of Pathology, College of Medicine, Chung Ang University) ;
  • Song, Ke-Yong (Department of Pathology, College of Medicine, Chung Ang University) ;
  • Jeon, Ku-Seok (College of Pharmacy, Chung Ang University) ;
  • Huh, In-Hoi (College of Pharmacy, Chung Ang University)
  • 발행 : 1988.08.29
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초록

This study was undertaken to elucidate the role of L-carnitine on cardiotoxicity induced by doxorubicin in mice. We designed to investigate both lipoperoxidation and histopathology in experimental group. The results obtained from prior with concurrent treatment of L-carnitine showed as follows; 1) Combination of L-carnitine showed significant inhibition of lipoperoxide in liver than heart. 2) By means of electron microscopy, we obtained histological evidence that doxorubicin-induced cardiomyopathy, is prevented by L-carnitine.

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