Archives of Pharmacal Research
- 제11권1호
- /
- Pages.65-73
- /
- 1988
- /
- 0253-6269(pISSN)
- /
- 1976-3786(eISSN)
Effects of Clonidine on the Negative Chronotropic Response Induced by Vagal Stimulation in the Rat
- Hong, Sung-Cheul (Department of Pharmacology, College of Pharmacy Pusan National University) ;
- Huh, Kyung-Hye (Department of Pharmacology, College of Pharmacy Pusan National University) ;
- Chung, Joon-Ki (Department of Pharmacology, College of Pharmacy Pusan National University) ;
- Park, Mi-Sun (Department of Pharmacology, College of Pharmacy Pusan National University)
- 발행 : 1988.03.01
초록
The effects of clonidine on the negative chronotropic response induced by stimulation of vagus nerve were studied in the presence of propranolol in reserpinized and anesthetized rats. When the heart rate was decreased by stimulation of the vagus nerve, clonidine significantly inhibited vagally induced heart rate decrease (negative chronotropic response) in dose dependent manner. This inhibitory effect of clonidine was virtually abolished by phentolamine,
키워드