Archives of Pharmacal Research
- Volume 11 Issue 1
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- Pages.7-13
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- 1988
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Cytochrome C methylation: Current Knowledge of its Biological Significance
- Park, Kwang-Sook (Fels Research Institute, Temple University School of Medicine) ;
- Frost, Blaise F. (Fels Research Institute, Temple University School of Medicine) ;
- Lee, Hyang-Woo (School of Pharmacy, Sung Kyun Kwan University) ;
- Kim, Sang-Duk (Fels Research Institute, Temple University School of Medicine) ;
- Paik, Woon-Ki (Fels Research Institute, Temple University School of Medicine)
- Published : 1988.03.01
Abstract
The yeast cytochrome c gene has been recloned, and the resulting cytochrome c mRNA has been translated in rabbit reticulocyte lysate translation system. The newly synthesized apocytochrome c could be methylated by exogenously added cytochrome c-lysine N-methyltransferase. Enzymatic methylation of in vitro synthesized apocytochrome c was found to facilitate specifically its import into mitochondria of yeast, but not of rat liver.