Development and Structural Activity Relationship of New Local Anti-inflammatory Steroid, Prednisolone Deribatives

국소적용 소염제인 Prednisolone 유도체의 개발 및 구조와 활성의 상관관계(II)

New prednisolone derivatives including methyl $20{\xi}-acetoxy-prednisolonate$ have been synthesized and evaluated for local anti-inflammatory agents with reduced systemic side effect. Methyl $20{\beta}-dihydroprednisolonate$ and methyl $20{\xi}-acetoxyprednisolonate$ showed comparable anti-inflammtory activity in vivo with significantly reduced systemic side effects.