Korean Journal of Head & Neck Oncology (대한두경부종양학회지)
- Volume 3 Issue 1
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- Pages.85-90
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- 1987
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- 1229-5183(pISSN)
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- 2586-2553(eISSN)
Syndrome of Inappropriate ADH Secretion Associated with Laryngeal Carcinoma, Cured by Total Laryngectomy
후두암에 동반된 SIADH
- Yoon Seok-Keun (Department of Otolaryngology, College of Medicine, Yeungnam University) ;
- Choi Byung-Heun (Department of Otolaryngology, College of Medicine, Yeungnam University) ;
- Park Hun-Woong (Department of Otolaryngology, College of Medicine, Yeungnam University)
- Published : 1987.09.01
Abstract
The syndrome of inappropriate ADH secretion(SIADH) is a clinical disorder in which there is continual release of antidiuretic hormone(ADH) unrelated to plasma osmolality. It may occur usually in association with malignant tumors below the clavicle and other pulmonary disorders which are capable of synthesizing, storing and releasing ADH into the circulation but rarely with the head and neck tumors yet. We experienced a patient with unexplained hyponatremia associated with laryngeal carcinoma. The clinical and laboratory diagnostic studies suggested that patient's sodium deficiency was secondary to the SIADH. Subsequent resection of the neoplasm, total laryngectomy led to resolution of hyponatremia, suggesting that a tumor associated humoral factor, such as vasopressin or vasopressin like substance, was responsible for the electrolyte disturbance.
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