Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
권호 표지

Lipid Peroxidation in Vivo Monitored as Ethane Exhalation in Hyperoxia

호기중 에탄(ethane)측정을 통한 산소중독시 지질과산화평가에 관한 실험적 연구

  • Song, Jae-Cheol (Department of Preventive Medicine, College of Medicine, Seoul National University) ;
  • Cho, Soo-Hun (Department of Preventive Medicine, College of Medicine, Seoul National University) ;
  • Chung, Myung-Hee (Department of Pharmacology, College of Medicine, Seoul National University) ;
  • Yun, Dork-Ro (Department of Preventive Medicine, College of Medicine, Seoul National University)
  • 송재철 (서울대학교 의과대학 예방의학교실) ;
  • 조수헌 (서울대학교 의과대학 예방의학교실) ;
  • 정명희 (서울대학교 의과대학 약리학교실) ;
  • 윤덕로 (서울대학교 의과대학 예방의학교실)
  • Published : 1987.11.01
Download PDF
⟨ Previous Next ⟩

Abstract

In vivo ethane production in rats was used as an index of oxygen toxicity. The rats were allocated to four exposure conditions; hyperbaric oxygenation (HBO=5 ATA, 100% $O_2$), normobaric oxygenation (NBO=1 ATA,100% $O_2$), hyperbaric aeration (HBA=5 ATA, 21% $O_2$) and normobaric aeration (NBA=1 ATA, 21% $O_2$). After 120 minutes of exposure, the rats exposed to high concentration and/or high pressure oxygen exhaled significantly larger amounts of ethane than those exposed to NBA, and the differences in ethane production between any two groups were statistically significant (p<.01). This finding supports the hypothesis that hyperoxia increases oxygen free-radicals and the radicals produce ethane as a result of lipid peroxidation. It is notable that the ethane exhalation level of the HBA group was significantly higher than that of the NBO group. This difference could not be accounted for by the alveolar oxygen partial presure difference between the two groups.

Keywords