대한미생물학회지 (The Journal of the Korean Society for Microbiology)
- 제22권2호
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- Pages.155-162
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- 1987
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- 0253-3162(pISSN)
최근 분리된 장내 병원성 대장균의 항균제 감수성
In Vitro Susceptibility of Diarrhea-Causing Escherichia coli to 9 Antibacterial Agents in Clinical Use
- 김재호 (한양대학교 의과대학 미생물학교실) ;
- 김경희 (한양대학교 의과대학 미생물학교실) ;
- 조양자 (한양대학교 의과대학 미생물학교실) ;
- 서인수 (한양대학교 의과대학 미생물학교실)
- Kim, Jai-Ho (Department of Microbiology, College of Medicine, Hanyang University) ;
- Kim, Kyung-Hee (Department of Microbiology, College of Medicine, Hanyang University) ;
- Cho, Yaug-Ja (Department of Microbiology, College of Medicine, Hanyang University) ;
- Suh, Inn-Soo (Department of Microbiology, College of Medicine, Hanyang University)
- 발행 : 1987.06.30
초록
To determine the prevalence of antibiotic resistance in fecal E. coli and to investigate possible associations between antibiotic resistance and other plasmid-mediated virulence properties, antibiotic disk susceptibility tests for nine antibiotics were done on 141 strains of E. coli isolated from diarrheal children and well controls. Eighty two percent of the test strains were resistant to one or more antibiotics. Antibiotics to which the test strains were most resistant in descending order were ampicillin (85%), trimethoprim/sulfamethoxazol (60%), and cephalothin (55%). Seventy nine percent of these resistant strains were resistant to two or more antibiotics. All 141 test strains were sorted into enterotoxigenic E. coli (ETEC), enteropathogenic E. coli (EPEC), enteroadherent E. coli (EAEC) and non-pathogenic E. coli and the percentages of strains resistant to multiple antibiotics were compared. Among ETEC regardless of its source, multiple drug resistance was more frequent in strains producing heatstable enterotoxin (ST) only than in strains producing only heat-labile enterotoxin (LT) or both. In EAEC, multiple resistance was more frequently associated with strains isolated from diarrheal patients than with those from well controls. The major antibiotic resistance patterns possessed by multiple resistant enteropathogenic strains were