The Journal of the Korean Society for Microbiology (대한미생물학회지)
- Volume 22 Issue 3
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- Pages.323-328
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- 1987
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- 0253-3162(pISSN)
Effect of Inosiplex on the Cell-mediated Immune Response of Patients with Lepromatous Leprosy
Inosiplex가 나종형 나환자의 세포성 면역반응에 미치는 영향
- Lee, Hern-Ku (Department of Microbiology and Immunology, Chonbuk National University Medical School) ;
- Im, Suhn-Young (Department of Microbiology and Immunology, Chonbuk National University Medical School) ;
- Park, Young-Min (Department of Microbiology and Immunology, Chonbuk National University Medical School) ;
- Chung, Kyi-Whan (St. Mary's Clinic) ;
- Ha, Tai-You (Department of Microbiology and Immunology, Chonbuk National University Medical School)
- 이헌구 (전북대학교 의과대학 미생물학교실) ;
- 임선영 (전북대학교 의과대학 미생물학교실) ;
- 박영민 (전북대학교 의과대학 미생물학교실) ;
- 정귀환 (전북 이리 성모의원) ;
- 하대유 (전북대학교 의과대학 미생물학교실)
- Published : 1987.09.30
Abstract
This study was attempted to investigate the effect of inosiplex on the cell-mediated immunity in the patients with lepromatous leprosy. Fourteen patients received inosiplex (6gm/day) for 1 month. About 20% of the patients (3 of 14) showed conversion of the lepromin reaction and bacteriological index was significantly decreased in 3 of 7 patients. However, inosiplex administration had no effect on the lymphocyte blastogenesis to M. leprae. The clinical evolution showed a favorable activity of the drug on cutaneous lesions in some patients. The tolerance of the drug was excellent. No side effects were observed. These results suggest that inosiplex may have a moderate immunopotential value in lepromatous leprosy.