대한미생물학회지 (The Journal of the Korean Society for Microbiology)
- 제22권3호
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- Pages.275-282
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- 1987
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- 0253-3162(pISSN)
Augmentin(Amoxycillin/clavulanic acid)의 시험관내 항균효과
Antibacterial Activity of Amoxycillin/Clavulanic Acid(Augmentin) in Vitro
- Shim, Woo-Nam (Department of Microbiology, Yonsei University College of Medicine) ;
- Youn, Jung-Koo (Department of Microbiology, Yonsei University College of Medicine)
- 발행 : 1987.09.30
초록
Strains of bacteria resistant to beta-lactam antibiotics have been increasing in number and are becoming troublesome in clinical medicine. The in vitro antibacterial activity of augmentin, a combination drug consisting of two parts amoxycillin to one part clavulanic acid, a potent beta-lactamase inhibitor, and their minimum inhibitory concentrations were determined by an agar dilution technique against ampicillin-resistant clinical isolates in Korea. Of the 226 strains tested, 140 strains(62%) were resistant to ampicillin. Among the 140 ampicillin-resistant strains, all Salmonella spp. Proteus spp. the majority of S. aureus and Shigella spp. were sensitive to augmentin. Ps. aeruginosa remained 100% resistant and there has been a considerable decline in resistant strains in E. coli and K. pneumoniae although a significant percentage of strains showed intermediate sensitivity. The minimum inhibitory concentrations of augmentin were ranged in
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