대한핵의학회지 (The Korean Journal of Nuclear Medicine)
- 제21권2호
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- Pages.133-141
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- 1987
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- 1225-6714(pISSN)
방사면역측정법에 의한 갑상선 자가항체 측정의 기본적 및 임상적 검토
The Analysis of the Value of the Thyroid Autoantibody Measured by Radioimmunoassay
- 정재훈 (서울대학교 의과대학 내과학교실) ;
- 이명식 (서울대학교 의과대학 내과학교실) ;
- 조보연 (서울대학교 의과대학 내과학교실) ;
- 이홍규 (서울대학교 의과대학 내과학교실) ;
- 고창순 (서울대학교 의과대학 내과학교실) ;
- 민헌기 (서울대학교 의과대학 내과학교실) ;
- 이문호 (서울대학교 의과대학 내과학교실)
- Chung, Jae-Hoon (Department of Internal Medicine, College of Medicine, Seoul National University) ;
- Lee, Myung-Shik (Department of Internal Medicine, College of Medicine, Seoul National University) ;
- Cho, Bo-Youn (Department of Internal Medicine, College of Medicine, Seoul National University) ;
- Lee, Hong-Kyu (Department of Internal Medicine, College of Medicine, Seoul National University) ;
- Koh, Chang-Soon (Department of Internal Medicine, College of Medicine, Seoul National University) ;
- Mim, Hun-Ki (Department of Internal Medicine, College of Medicine, Seoul National University) ;
- Lee, Mun-Ho (Department of Internal Medicine, College of Medicine, Seoul National University)
- 발행 : 1987.11.13
초록
To evaluate the values of the thyroid autoantibody measured by radioimmunoassay (RIA) and compare it with hemagglutination method (HA) in the normal and the thyroid disease, data were obtained from total 618 persons; 236 healthy persons, 217 patients with Graves' disease (including 113 patients with undertreated Graves' disease), 100 Hashimoto's disease, 31 thyroid nodule, and 34 simple goiter. RSR kit made in England was used and could be detected to at least 3 U/ml. The positive rates of normal group were antimicrosomal antibody (AMA) 31.8%, antithyroglobulin antibody (ATA) 44.5% by RIA and there was no considerable change in sex and age distribution. In Graves' disease, the positive rates of AMA and ATA were 90.4, 76.9% by RIA, 85, 39% by HA. In Hashimoto's disease, 94,91 % by RIA, and 87,48% by HA, respectively. The autoantibody titer by RIA in thyroid autoimmune disease as well as in normal group was more senisitive than that by HA, especially in ATA. There were linear relationships between the titer of RIA and that of HA in AMA of Graves' disease and AMA and ATA of Hashimoto's disease. There was no relationship among thyroid autoantibody, free
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