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Synthetic $\beta$-Lactam Antibiotics II. Synthesis and Antibacterial Activity of 7$\beta$-[2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido]-3-[1-(halosubstitutedphenyl)-1H-tetrazol-5-yl]thiomethyl-cephalosporins

  • Koh, Dong-Soo (Organic Chemistry Lab., Korea Advanced Institute of Science & Technology) ;
  • Kim, Joong-Hyup (Organic Chemistry Lab., Korea Advanced Institute of Science & Technology) ;
  • Park, Sang-Woo (Organic Chemistry Lab., Korea Advanced Institute of Science & Technology) ;
  • Kim, You-Seung (Organic Chemistry Lab., Korea Advanced Institute of Science & Technology)
  • Published : 1987.10.20

Abstract

Syntheses of cefotaxime analogs with halosubstituted phenyltetrazolthiomethyl at the $C_{3^-}$position are described. Their in vitro potency was established. The compounds exhibited a broad antibacterial spectrum. Some of these compounds showed activity against Gram-positive bacteria superior to the parent cefotaxime. Against Gram-negative bacteria, these compounds are less effective than cefotaxime.

Keywords

References

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Cited by

  1. Development of an Isolable Active Ester, Diethyl Thiophosphoryl [(Z)-(2-Aminothiazol-4-yl)-2-(Methoxyimino)acetate (DAMA) for the Synthesis of Cefotaxime vol.32, pp.2, 1987, https://doi.org/10.5012/bkcs.2011.32.2.407